Viagra - Wonder Drug for impotence. Viagra home page.Bookmark this page and check back here frequently, we update daily.VIAGRA ™- Home Page, an oral therapy for erectile dysfunction (VERY BUSY SITE)Viagra information from Arnot Ogden Medical Center. Free Viagra information.Viagra FAQ, also from Arnot Ogden Medical Center. How does it work, how long, etc.Safety and Efficacy Data on Viagra - Pfizer Oral Drug for Impotence. Manufacturer of Viagra.Viagra package insert - FDA approved information from Pfizer. (very busy site)Potent pills promise help for impotence (AP, The Daily News) - Viagra, Apomorphine, VasomaxPublic clamors for Viagra. Is it going to be misused? Of course it will, sex sells.Pfizer press release on Viagra (site is a bit overwhelmed right now).Urological Sciences Research Foundation - lots of viagra information and links.Sexual Health Center organization - Viagra information and links free viagra.FEATURE-Men get worked up over new impotence pill. "men are excited about Viagra"FDA Approves First Impotence Pill, Viagra. From the Washington Post.Rules for Sex Pill: New York seeks to Bar Thrill Seekers. State may regulate Viagra. Frequent Orgasms May Lengthen Lives of Men, British Study Finds (Dec. 23, 1997)
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Commentary: (some may include adult content)Wonder Drug for Women: But only men are allowed to have it!
Viagra (Sildenafil) information for patients; How to avoid getting ripped off; also how does Viagra work; Viagra cost, Viagra side effects, dose, mechanism of action, warnings; price comparison; what is a PDE5 Enzyme Inhibitor?
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*Lowest price for Viagra in the United States allowed by law! MONEY BACK GUARANTEE
Viagra Information DatabaseBy Corey Nahman, Registered Pharmacist (NYS 35518)
People always ask "Where's the best place to buy Viagra?" We investigated the top websites that sell Viagra before we wrote this page. It's difficult to know what to look for in order to find legitimate Viagra websites.
You need to know that:
- Half the Viagra sold on the internet is fake.- Most of the websites that sell Viagra are located in 3rd world countries but they lie and pretend to be American or Canadian.- There is no such thing as generic Viagra.
Things To Be Suspicious Of:
- You want to make sure there is a physical address on the website selling the Viagra. It should be a real address, not a P.O.box. If there is no address that is a bad sign.
Why would someone want to hide their address? No address means that they are deliberately making it hard for you to track them down in case there is a problem.
- They should have a toll free telephone number. If something goeswrong you want to be able to speak to a real live person. It is veryfrustrating to only be able to communicate by e-mail when you havea problem.
************************************************************COMPARISON SHOP 10 sites that sell Viagra. Make them compete for your business. Click Here to Comparison Shop For Viagra************************************************************
Viagra Buying Tips
- Test the telephone number before you place your order. Askthe person who answers the phone where the product is shipped from.If they don't answer to your satisfaction, it's a bad sign.
- Ask them if they do the shipping and handling or if they only do the billing.
There is a good chance that the person on the other end of the phoneis just a go-between; a clerk in front of a credit card machine, doing the billing for hundreds of Viagra websites.
In many instances, they have no idea who the Viagra merchant is; allthey know is that once a month they get a commission check fromsomeone they have never seen or met in person.
Their job is answering the phone and ringing up your sale. After yourcredit card has been charged, the relationship is over.
- You get what you pay for. If it seems too good to be true, it probably is too good to be true. You are better off paying $10.00 per pill at your local drugstore and getting genuine American Viagra than paying $6.00 for a so-called generic Viagra on the internet and getting a fake.
- Your first purchase should be for a small quantity of pills. Don't start of with thirty tablets. Buy five or ten. Make sure the Viagra is legit and the shipping and billing goes smoothly before you make a large purchase.
You should never deal with a site from Russia or Nigeria, places where identity theft is common. Scammers in these countries have been known to set up sham Viagra web sites just so they could steal your credit card information.
Did you know that Pfizer (the only legitimate manufacturer of Viagra) has a program whereby they offer one free Viagra tablet for every 3 pills you buy? Click Here to view the Pfizer Value Card.
Where does it come from?
A lot of the bootleg Viagra comes from Costa Rica and other South American countries where the laws regarding pharmaceuticals are lax.
Most of the Viagra selling websites are fly-by-night operations lookingto make a quick buck. They often masquerade as American or Canadian internet pharmacies but they are usually located outside the law in countries such as Cambodia or Bulgaria.
Real or Fake? What's The Big Deal?
Many sites sell counterfeit Viagra to unsuspecting people at highly inflated prices.
Sometimes they sell you a little baggie of half-tablets and Viagracrumbs. And when you try to call the "1-800" telephone number onthe site you brought the pills from to complain, all you get is the run-around.
Another common scheme is that people try to sell you sell so-calledgeneric Viagra. Generic drugs made in countries outside the US, Canada and Western Europe are likely to be substandard.
In fact, wealthy people in poor countries often buy their medicines from America because they know not to trust the medicines that come fromtheir own countries!
It is common for expatriates visiting their home countries to buy medicine and take it back home with them for their ailing parents because drugs from America are considered to be very safe and effective.
The poorer the country is, the easier it is to bribe local officials to look the other way. One hundred dollars goes a long way out in the boondocks of China or Mexico. If you live in one of these countries, it is easy to open a pill factory to manufacture fake Viagra.
These little factories are like meth labs - they stay open a short while, manufacture several thousand bootleg or counterfeit pills and move on before they get caught.
When you buy Viagra on the internet without a prescription, expect topay a lot more that you would normally pay - like $20.00 or $30.00 per pill. In the US, Viagra costs no more than $9.00 or $10.00 per pill.
If you buy a larger quantity you should pay less per pill. If you buy asmaller quantity you will pay more per pill.
In general, the farther away the Viagra seller is, the easier it is for them to rip you off.
Avoid buying Viagra from Asia, South America, Mexico and theCaribbean because that's where a lot of the fake Viagra comes from.
Another reason to avoid buying Viagra from outside the United States is the pills might be confiscated by postal authorities when they reachthe United States.
This is happening more and more each day as the FDA and the DEAcrack down on the illegal importation of drugs into the USA.
Viagra Information On The Internet:
Viagra Price Comparison: There is a lot of competition between sitesthat sell Viagra. This competition drives down the prices. Our editors have searched the internet. You should be able to get a good price on genuine Viagra if you comparison shop.
Viagra.comOfficial website; Geared to patients; all about Viagra and erections. Includes an offer for 6 free pills of Viagra.
ViagraMD.comOfficial Viagra website for healthcare professionals; How to start andmaintain patients on Viagra, Multimedia presentation, prescribing information, etc. This site also has a section where you can report anadverse regarding Viagra.
Official Viagra Prescribing Information (Package Insert); dose, mechanism of action, side effects, precautions,warnings; patient information; very technical, don't get scared whenyou come to the section on warnings and side effects.
- Viagra FDA Consumer InformationWho should avoid Viagra, precautions, side effects.
- Viagra Scientific Papers National Library Of Medicine; automated Medline search; a listing of scientific papers in condensed form regarding Viagra.
- Viagra Versus Levitra From Forbes magazine 10/06/03; M. Herper and A. Lagorce; Side by side comparison of various characteristics; cost, pharmacokinetics, marketing tactics, etc.
- Viagra Versus Cialis From Forbes magazine 12/03/03; M. Herper; side by side comparison of various characteristics in slide show format.
- Viagra News (from Google) ; recently published news regarding Viagra.
What Is Viagra and How Does It Work?
All three of the erectile dysfunction drugs (Viagra, Levitra and Cialis)are similar in action. They block an enzyme that causes an erection to go flaccid. Although these drugs are similar in action, their dose, onset of action time and duration of action differ.
Viagra (Sildenafil) is a member of a family of drugs called PDE5 Inhibitors. Viagra was the first PDE5 inhibitor on the market. FDA was approved Viagra on March 27, 1998. The team of scientists who discovered Viagra won the Nobel Prize.
The BIG Discovery: cyclic guanosine monophosphate (cGMP)
Some very smart scientists discovered that cyclic guanosine monophosphate (cGMP) was the key to sustaining an erection.
They discovered that when a man gets sexually stimulated, a chain reaction occurs in the tissue of the penis that results in elevated levels of a substance called cyclic guanosine monophosphate (cGMP).
As long as there are sufficient levels of cGMP, the penis can remainerect. The more cGMP, the more robust and durable the erection.
If you inhibit the degradation (breakdown) of cGMP it stays around in the penis longer, producing a more durable erection.
Another way you can think of Viagra (and all other similar medicines) is that it preserves the elevated levels of cGMP that are created when a man is sexually stimulated for a stronger, more lasting erection.
That's how Viagra works - Viagra blocks the enzyme phosphodiesterase-5 (PDE5) which is responsible for the neutralization of cGMP. Viagra (Sildenafil) is a highly selective inhibitor of PDE5. (PDE5 is not the only phosphodiesterase involved in the erectile physiology but it appears to be the most important one).
The nice thing about PDE5 blockers is that they shouldn't cause erections at inappropriate times because they only block degradation of cGMP produced in reaction to sexual stimulation, such as thinkingabout something sexy.
If you are not being sexually stimulated, there is no cGMP to protect, so the drug remains in the background.
Absorption, Bioavailability
Viagra is rapidly absorbed. Maximum observed plasma concentrations of Viagra are reached within 30 to 120 minutes (median 60 minutes) oforal dosing in the fasted state. Viagra is about 40% biovailable. Viagra is highly protein bound (96%). When Viagra is taken with a high fat meal, the rate of absorption is reduced.
Metabolism, Half Life, Excretion
Viagra is mostly metabolized in the liver by an enzyme known as CYP3A4 and to a lesser extent CYPC229. Viagra breakdown productsare excreted in the feces (80%) and in the urine (approximately 13%). Viagra's mean half life is about 4 hours.
If you are going to take any of the PDE5 inhibitors such as Viagra, it isvery important that your doctor be aware if you have a liver condition(such as cirrhosis) or kidney condition ( such as if you are on dialysis)because you may need a special dosage adjustment.
Likewise, if you try to obtain Viagra on the internet, please make surethat the person authorizing your prescription knows the true status ofyour liver function and your kidney function.
Dose:
For most patients, the recommended dose of Viagra is 50mg taken about 1 hour prior to anticipated sexual activity. However, the Viagra label states that it can be taken anywhere from 1/2 hour to 4 hours prior to sexual activity.
The dose of Viagra may be increased to 100mg or decreased to 25 mgdepending on efficacy and side effects. Sometimes people buy the100mg tablets and break them in half to save money.
Viagra is available 25mg and 50mg and 100mg tablets.
The maximum recommended dose is one pill per day.
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Important safety information
VIAGRA is prescribed to treat erectile dysfunction (ED).
If you take any medicines that have nitrates in them (like nitroglycerin for chest pain)—every day or even once in a while—you should NOT take VIAGRA.
Discuss your general health status with your doctor to ensure that you are healthy enough to engage in sexual activity. If you experience chest pain, nausea, or any other discomforts during sex, seek immediate medical help.
The most common side effects of VIAGRA are headache, facial flushing, and upset stomach. Less commonly, bluish vision, blurred vision, or sensitivity to light may briefly occur.
In rare instances, men taking PDE5 inhibitors (oral erectile dysfunction medicines, including VIAGRA) reported a sudden decrease or loss of vision. It is not possible to determine whether these events are related directly to these medicines or to other factors. If you experience sudden decrease or loss of vision, stop taking PDE5 inhibitors, including VIAGRA, and call a doctor right away.
Although erections lasting for more than 4 hours may occur rarely with all ED treatments in this drug class, to avoid long-term injuries, it is important to seek immediate medical help.
If you are older than age 65, or have serious liver or kidney problems, your doctor may start you at the lowest dose (25 mg) of VIAGRA. If you are taking protease inhibitors, such as for the treatment of HIV, your doctor may recommend a 25-mg dose and may limit you to a maximum single dose of 25 mg of VIAGRA in a 48-hour period.
If you have prostate problems or high blood pressure for which you take medicines called alpha blockers, your doctor may start you on a lower dose of VIAGRA.
Remember to protect yourself and your partner from sexually transmitted diseases.
VIAGRA is one of many options for treating ED that you and your doctor can consider.
*Program only counts for pills not covered by insurance.
Please see full prescribing information for VIAGRA (25-mg, 50-mg, 100-mg) tablets.
*Save up to $75 off every 4th prescription. Total savings cannot exceed $150 in a year.
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August 13, 2007
VGU00136
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